Some Observations on Thiouracil Neutropenia, with Special Reference to the Sternal Marrow.
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چکیده
منابع مشابه
The effects of drugs that cause neutropenia upon colony formation by bone marrow cells in semi-solid agar.
1. The effect of drugs that cause neutropenia has been tested upon normal bone marrow colony formation in semi-solid agar. 2. Thiouracil, methimazole and phenylbutazone do not cause inhibition whereas sodium aurothiomalate, 6-mercaptopurine and chloramphenicol cause doserelated inhibition of colony formation at or below drug concentrations found in serum during therapy. Chloramphenicol also inh...
متن کاملMorphological examination of the blood and sternal marrow on nine patients treated with thiouracil.
By CARL J. GESSLER, M.D. B ECAUSE of the current interest in agranulocytosis following thiouracil administration it was determined to study the blood and bone marrow in a series of 9 patients under treatment with this drug for hyperthyroidism. It is of interest that before treatment was instituted the total leukocyte count in 4 of the 9 cases was less than 4,000 per cu. mm., with a correspondin...
متن کاملSternal marrow studies in thyrotoxicosis treated with thiouracil and review of literature regarding thiouracil effects on blood.
A review of the available literature to date shows 1914 casest of thyrotoxicosis in which thiouracil was employed. This does not include the use of thiourea or other related compounds nor the use of thiouracil in any condition but thyrotoxicosis. Forty-four cases (1.3 per cent) had resulting agranulocytosis, and of these, i per cent) died because of the agranulocytosis. Ninety-three patients pe...
متن کاملThe effect of thiouracil on leukemia.
By LOUIS R. LIMARZI, M.D., RICHARD J. KULASAVAGE, M.D., AND CONRAD L. PIRANI, M.D. O NE of the toxic reactions of therapeutic doses of thiouracilt in the treatment of hyperthyroidism is the development of granulocytopenia. A nonfatal granulocytopenia and a fatal type of agranulocytosis have been reported. The selective action of thiouracil on the granulopoietic tissue is the basis for the prese...
متن کاملThe Effects of Pyridoxine and Folic Acid on Thiouracil-induced Granulopenia in Monkeys *
In the repore in which Astwood described the use of thiouracil for the treatment of human thyrotoxicosis he was fortunately able to indicate the most serious hazard which the administration of this drug entails, that of agranulocytosis. A great volume of work has confirmed both the effect of thiouracil on thyroid hyperfunction and its occasionally toxic effect on the bone marrow. Since this idi...
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عنوان ژورنال:
- Journal of clinical pathology
دوره 1 5 شماره
صفحات -
تاریخ انتشار 1948